Interesting things I notice from the cast page:
-It seems like a bunch of minor characters made the cut. Bob & Elmer almost seem tossed in as a joke as of right now (they're the two guys who get briefly seen in many background shots if I'm not mistaken), but you never know, maybe they just want to avoid "WHUHHH? Who are THESE GUYS?" topics if they ever actually WRITE stuff about these two. Same goes from Fred & Daphne, Cyndi and Samantha (she's said what, three things?)
-Tossing in bios for all the anti-Penny people (Karen, Samantha, Meg and possibly Cyndi) while at the SAME TIME mentioning in each bio that they dislike Penny (or in Cyndi's case, haven't chosen a side), pretty much makes it clear that something big's about to happen on that front. Sorta like those moments in a movie where the bad guys get all their soldiers in a big line after spending 40 minutes building them up, and prepare to go to war. REALLY looking forward to that storyline.
-Something tells me T & Gisele were sick of repeatedly asked questions, and decided to put them up in the bios themselves.
I can imagine they'll get fewer "Where do Karen & Marshall go to high school?" questions finally. And thankfully they've finally commented on the Sara & Stan homosexual implications instead of leaving it up solely to fan speculation. Other FAQs they probably nailed here: Marshall's father, why Helen's got no spine, and why Katy-Anne fits in with the Alphas.
-Interesting; Michelle's family being poorer is brought up again. That was almost a dropped topic from way early in the strip (one of the first 'back to school' strips seemed to actually imply Michelle was moving away FOREVER and that Penny expected never to see her again), but obviously we're going to see more of it.